This book was inspired by a sustainable life-span approach on conceptual design, which took into account economics and potential losses throughout the course of the process life span. This chapter provides a description of the technological and scientific situations that were employed in the research. It is divided into the following sections: A overview of the literature on current techniques for the synthesis and design of reactive distillation columns is presented in Chapter 2. The achievable region approach and its application to simultaneous reaction, mixing, and separation processes are also explained in this chapter. In order to obtain the requisite selectivity in the vande Vusse scheme for ideal mixes comprising inerts, Chapter 3 proposes a new methodology for the synthesis and construction of single-feed hybrid reactive distillation columns (columns featuring both reactive and non reactive sections). It is based on a method of graphical simulation. In order to achieve the desired selectivities for van de Vusse schemes involving multicomponent zeotropic/multiazeotropic mixtures containing inerts in which one or more than one product can undergo further side reaction, Chapter 4 provides a methodology for the conceptual design of simple and complex hybrid RD columns (s). Based on a mixed graphical simulation approach, this methodology. The significant accomplishments and conclusions are highlighted in Chapter 5, which is followed by the scope of additional research.