This book deals with the extractive distillation of isopropanol(IPA)-water azeotropic mixture by using dimethylsulphoxide(DMSO) as an extractive agent. IPA is found in numerous household and commercial products, including rubbing alcohol, antifreeze, disinfectants, cleaning solutions, skin and hair products, and hand sanitizers. In this way, it is utilized generally as a solvent and as a cleaning liquid, particularly to dissolve oils. It is also used as chemical intermediates, for medical application, drying agents, pharmaceuticals and also as a fuel additives IPA is commonly used as a solvent for industrial applications. 2-Propanol (isopropyl alcohol; IPA) – water mixture reflects a homogeneous minimum-boiling azeotrope (at 80.3-80.4 °C, 87.4-87.7 wt.%). Some methods of enhanced distillation of this mixture have been developed, Such as azeotropic distillation, reactive and extractive distillation, and membrane separation either in the form of membrane distillation or pervaporation. Due to this close boiling point azeotrope does not separate by conventional distillation but may be competently separated by extractive distillation. Extractive distillation is a separation technique which separates close-boiling binary mixtures by addition of a third component which increases the relative volatility between the two original components. First feed with solvent charged into Othmerstill apparatus and being heated till the steady state is reached. So that IPA rises in purity passing the azeotropic point. Finally distils it to achieve higher composition or pure T. The results thus obtained in separating isopropanol- water mixtures by using dimethyl sulphoxide (DMSO) as an extractive agent, are compared with those for an established extractive distillation processes. The entrainer is then removed from the mixture by a second distillation step. It is also shown how the energy consumption, cost of solvent in the entire plant can be minimized.